Where treatment with N-acetylcysteine is clinically indicated, current weight up to a maximum of 110kg should be used to calculate dosing. Treatment with N-acetylcysteine should not be withheld on the basis of pregnancy. There is evidence linking a delay in treating a pregnant patient with N-acetylcysteine with increased fetotoxic effects. Maternal treatment of paracetamol overdose should be as for the non-pregnant patient. There is evidence that the fetal liver begins to metabolise paracetamol from 18 weeks gestation onwards, therefore the fetus may also be at risk for hepatotoxicity following maternal paracetamol overdose at and beyond this stage. ![]() There are limited published data on fetal outcomes following paracetamol overdose during human pregnancy, however the information available does not suggest an increased risk of congenital malformation or fetal loss in the absence of severe maternal toxicity.
0 Comments
Leave a Reply. |